josh bis : unfamous epidemiologist
Our paper about genetic predictors of hippocampal volume in the CHARGE consortium appeared [#] alongside another paper on the genetics of brain structure from our colleagues in the ENIGMA consortium [#] last week in Nature Genetics. This turned out to be a great learning experience, since I confess that before taking on this project, I had to do a quick wikipedia refresher on the brain’s little seahorse of memory [#].
“Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.” — a long-simmering project from the CHARGE inflammation working group made it into print this year in the European Heart Journal.
Among the results is the finding that although Lp-PLA2 levels are reliably associated with coronary heart disease, the variant most strongly predictive of these levels (the PLA2G7 gene, which encodes the protein) was not associated with coronary artery disease in a large independent sample.
“New gene functions in megakaryopoiesis and platelet formation” [nature]
A very minor role in this massive hematology genetics project.






